Bible scholar Bachmann is murdered in front of his daughter Johanna. Together with his assistant Simon, a French religious scholar, the young policewoman sets out to find her father's murderer. In the process, they stumble upon the trail of the mysterious Bible code, which is said to be able to prophesy the future of mankind. Pursued by the powerful Cardinal Rhades, Johanna and Simon become involved in a murder plot against the Pope in the Vatican. But not only his life is in danger - the existence of mankind is at stake. In order to prevent the cardinal's plans, it becomes all the more urgent to actually find the key to the Bible code. In a monastery, they discover the last important clue that leads them to the Israeli desert. There, a merciless race ensues for one of the last great secrets of Christianity...