The story of the Miami Police Department's vice squad and its efforts to end drug trafficking and prostitution, centered on the unlikely partnership of Sonny Crockett and Ricardo Tubbs - who first meet when Tubbs is undercover in a drug cartel.
Agent Joey Harden returns to assist Crockett as part of a new division, Youth Crime Unit, that was formed by a previous partner. The YCU investigates a college professor that has created a new designer drug, Bliss.