The Substance
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
Edward Hamilton-Clark
Fred
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Jiselle Henderkott
Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
TV Host
Vincent Colombe
Man in Suit #1 - Harvey's Office
Billy Bentley
Man in Suit #2
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Oscar Salem
2nd Assistant Director - Pump It Up Show
Viviane Bossina
Sue's Assistant
Matthew Luret
Floor Runner
Jana Bittnerová
Maria
Olivier Raynal
Alan - 2nd Agent
Tiffany Hofstetter
Stylist
Nicolas Royer
Guy in the Elevator
Nathan Rippy
Assistant Director - New Year's Eve Show
Manon Arizmendi
Little Girl - New Year's Eve Show
Virginie Kotlinski
Mother - New Year's Eve Show
Brett Gillen
Director of Photography - New Year's Eve Show
Charlotte Marquardt
Screaming Woman
Léa Hengl
Screaming Woman
Gaëlle Raymond
Screaming Woman
Claire Lemaire
Screaming Woman
Lila Boughoufala
Screaming Woman
Aurélien Lorgnier
Screaming Man
Ivan Sellier
Screaming Man
Philip Schurer
Screaming Man
Christian Bourmier
Shareholder
Martin Graham
Shareholder
Christian Bordeleau
Shareholder
Patrick Hamel
Shareholder
Didier Dhondt
Shareholder
Jacques-Yves Dorges
Shareholder
Jean-Claude Matthey
Shareholder
Olivier Jarcin
Shareholder
Jean-Luc Magneron
Shareholder
Charlotte Murray
Allison - Diner Waitress
Aaron Kahn
Greeting Person
Gabriela Arnon
Greeting Person
Nancy Josephson Lahoussine
Greeting Person
Andrew Eldridge
Greeting Person
Denise Powers
Greeting Person
Bryan Jones
Greeting Person
Adam Carage
Happy Birthday Person
Maria McClurg
Happy Birthday Person
Andrew Desmond
Happy Birthday Person
Rebecca Lafont
Happy Birthday Person
Laura Puech
Isabella
Ryan Chidester
Stagehand
Cécile Vogt
Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer
Yannick Guérin
Clumsy Burger Guy - Walk of Fame
Jean Miel
Worker Walk of Fame
Paul Descoings
Worker Walk of Fame
Benoit Lévêque
Worker Walk of Fame
Arthur Molinet
Cocktail Bartender
Manon Sachot
Cocktail Lounge Couple
Bastien Jorelle
Cocktail Lounge Couple
Kelly Hoarau
Female Assistant - Towel
Michel Juskiewicz
George - Harvey's Friend
Louise Greggory
Restaurant Waitress
Christophe Sartirano
Guy Looking at Sue
Florent Torres
Guy Looking at Sue
Romain Caldeira
Billboard Technician
Barthelemy Thomas
Billboard Technician
Axel Baille
Photographer
Ashley Lambert
Additional Voices (voice)
Ranjani Brow
Additional Voices (voice)
Chase Fein
Additional Voices (voice)
Shane Sweet
Additional Voices (voice)
William Calvert
Additional Voices (voice)
Michael Corbett
Additional Voices (voice)
Stephen Apostolina
Additional Voices (voice)
Yann Bean
The Substance (voice)
Audjyan Alcide
Pump It Up Show Dancer
Jonathan Jenvrin
Pump It Up Show Dancer
Mimi Maury
Pump It Up Show Dancer
Amelye Solange
Pump It Up Show Dancer
Kévin Table
Pump It Up Show Dancer
Laura Boera
Sparkle Your Life Show Dancer
Cissy Duc
Sparkle Your Life Show Dancer
Sophie Mercier
Sparkle Your Life Show Dancer
Marie Valton
Sparkle Your Life Show Dancer
Katrina Budzynski
New Year's Eve Show Dancer
Alicia Maury
New Year's Eve Show Dancer
Megane Adamik
New Year's Eve Show Dancer
Annalisa Pagnotta
New Year's Eve Show Dancer
Maelle Dantigny
New Year's Eve Show Dancer
Aleksandra Kedzierska Fontaine
New Year's Eve Show Dancer
Pauline Sagetat
New Year's Eve Show Dancer
Agustina Fitzsimons
New Year's Eve Show Dancer
Elena Shcheglova
New Year's Eve Show Dancer
Eve Marchant
New Year's Eve Show Dancer
Lola Donati
New Year's Eve Show Dancer
Kate Matthews
New Year's Eve Show Dancer
Ophélie Jonard
New Year's Eve Show Dancer
Pauline Richard
New Year's Eve Show Dancer
Laureen Cappelliez
New Year's Eve Show Dancer
Daria Panchenko
New Year's Eve Show Dancer
Delphine Beaulieu
New Year's Eve Show Dancer
Victoria Brun
New Year's Eve Show Dancer
Cara Chapman
New Year's Eve Show Dancer
Katharine Matthews
New Year's Eve Show Dancer
Alexandra Faget
New Year's Eve Show Dancer
Clémence Juville
New Year's Eve Show Dancer
Margot L'Entete
New Year's Eve Show Dancer
Hillary Sukhonos
New Year's Eve Show Dancer
Matthew Géczy
Bob Haswell (uncredited)
Namory Bakayoko
Silhouette (uncredited)
Gregory Defleur
Happy Birthday Person (uncredited)
Coralie Fargeat
(uncredited)
Matthieu de la Mortière
First Assistant Director
Anne Juin
Third Assistant Director
Erik Baiers
Executive Producer
Stanislas Reydellet
Production Design
Benjamin Kračun
Director of Photography
Jérôme Eltabet
Editor
Cécilia Blom
Set Decoration
Frédérique Arguello
Hair Department Head
Frédéric Balmer
Special Effects Makeup Artist
Denise Boccacci
Prosthetic Makeup Artist
Andrea Leanza
Prosthetics Sculptor
Sebastian Lochmann
Concept Artist
Richard Martin
Prosthetics Sculptor
Krystell Morantin
Assistant Art Director
Bryan Jones
Visual Effects Supervisor
Marie Bouvet
Stunt Double
Jérôme Gaspard
Stunt Coordinator
Guillemette Buffet
Stunt Double
Ahmed Chouikhi
Stunts
Joffrey Darel
Stunt Driver
Jérémie Delaboudinière
Stunts
Arthur Delapierre
Stunts
Stephane Girondeaud
Stunts
Lucile Perez
Stunts
Céline Richard
Stunts
Marie Sergeant
Stunts
Chloè Acher
Second Assistant Camera
Edouard Alvernhe
Electrician
Vianne Burquier
Camera Intern
Laure Caniaux
First Assistant Camera
Benjamin Colleye
Additional First Assistant Camera
Marie-Sophie Daniel
First Assistant Camera
Steve de Rocco
Camera Operator
Charles Droudun
Electrician
Yann Festinger
Video Assist Operator
Catherine Georges
Camera Operator
Tanguy Goasguen
Additional Grip
Thomas Gros
Key Grip
Gustin Guillaume
First Assistant Camera
Guillaume Lemerle
Gaffer
Stella Libert
First Assistant Camera
Nahi Margot
Electrician
Baptiste Marnière
Digital Imaging Technician
Olivier Maurin
Electrician
Jonas Poignant
Third Assistant Camera
William Renaud
Grip
Olivier Sargatal
Best Boy Electric
Christine Tamalet
Still Photographer
Ludovic Tobaldi
Steadicam Operator
Eddy Trouillot
Grip
Camille Damag
Costume Supervisor
Fabienne Menguy
Costume Supervisor
Noémie Lance
Location Manager
Nadege Marti
Location Scout
Katia Sourzac
Location Production Assistant
Baptiste Herment
Production Accountant
Fabien Pascal
Colorist
Benjamin Durfort
Assistant Editor
Baptiste Bonin
Props
Benjamin Bouygues-Faugeron
Property Buyer
Coralie Fargeat
Director
Coralie Fargeat
Producer
Eric Fellner
Producer
Tim Bevan
Producer
Alexandra Loewy
Executive Producer
Nicolas Royer
Executive Producer
Raffertie
Original Music Composer
Olivier Afonso
Special Effects Makeup Artist
Oriane Cattiaux
Makeup Artist
Marison De
Special Effects Makeup Artist
Sandrine Denis
Special Effects Makeup Artist
Dave Elsey
Prosthetic Supervisor
Lou Elsey
Prosthetic Supervisor
Stéphanie Guillon
Key Makeup Artist
Mélissa Jacob
Additional Hairstylist
Brian Kinney
Special Effects Makeup Artist
Lucky Nguyen
Makeup Artist
Bryony Rumble
Special Effects Makeup Artist
Cynthia Scigliuto
Makeup Artist
Caroline Vlieghe
Hairstylist
Julia Besnier
Production Accountant
Benjamin Celliez
Unit Production Manager
Pierre-Yves Frohard
Production Coordinator
Abraham Goldblat
Post Production Supervisor
Tiva Nagchin
Post Production Supervisor
Honorine Sutter
Assistant Production Manager
Clément Audebrand
Third Assistant Director
Mateo Cejoco
Third Assistant Director
Louis Tellier
Third Assistant Director
Benoit Seiller
Second Assistant Director
Louis Celnik
Carpenter
Marion Didier
Assistant Art Director
Elise Duvignau
Props
Barthelemy Thomas
Set Dresser
Amélie Meseguer
Assistant Set Decoration
Coralie Fargeat
Editor
Marjane Texier
Graphic Designer
Elsa Rolland
Assistant Property Master
Chloé Zobel
Property Master
Jean Miel
Special Effects Supervisor
Olaf Taittinger
Special Effects
Louis Auger
Digital Compositor
Téo L'Huillier
Digital Compositor
Guillaume Le Gouez
Visual Effects Supervisor
Louis Lion
Digital Compositor
Jacob Rogers
Digital Compositor
Guillaume Billy
Camera Trainee
Christophe Arnaud
Additional Second Assistant Camera
Thomas Burgess
Steadicam Operator
Jacques-Emmanuel Astor
Extras Casting
Raphaëlle Beck
Extras Casting
Aurélie Boutet
Casting Assistant
Elsa Manunta
Set Costumer
Jimmy Zhao
First Assistant Editor
Isalys Gillet
Location Assistant
Steve Sebir
Assistant Location Manager
Christophe Riso
Assistant Location Manager
Guillaume Baurez
Music Supervisor
Marianne Huet
Script Supervisor
Valentin Féron
Editor
Pierre-Olivier Persin
Prosthetics
Pierre-Olivier Persin
Makeup Effects Designer
Marion De Villechabrolle
Set Decoration
Stéphane Bécimol
Art Direction
Emmanuelle Youchnovski
Costume Designer
Claire Bernengo
Boom Operator
Patrick Christensen
ADR Mixer
Valérie Deloof
Sound Editor
Valérie Deloof
Sound Designer
Anna Devillaire
ADR Editor
Victor Fleurant
Sound Editor
Judah Getz
ADR Mixer
Olga Pasternak
Supervising Dialogue Editor
Margaux Peyre
Boom Operator
Thomas Pichon
Dialogue Editor
Victor Praud
Sound Re-Recording Mixer
Lucien Richardson
Supervising Dialogue Editor
Antoine Swertvaegher
Foley Editor
Stéphane Thiébaut
Sound Re-Recording Mixer
Emmanuelle Villard
Sound Mixer
Grégory Vincent
Foley Artist
Coralie Fargeat
Writer
Laure Cochener
Casting
Amélie Meseguer
Art Direction
Arnaud Denis
Art Direction
Gladys Garot
Art Direction
Julie Plumelle
Art Direction
Nathalie Vaïsse
Art Direction
Pierre Procoudine-Gorsky
Visual Effects Producer
Chevin Shafaghi
Visual Effects Supervisor
Serafin Bernfeld
Special Effects Technician
Arthur Weiser
Special Effects Technician
Alexandrine Mauvezin-Bosque
Set Dresser
Marilyne Scarselli
Key Hair Stylist
Jean-Marc Benois
Additional Hairstylist
Frédérique Arguello
Key Hair Stylist