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Babe Ruth
Babe (as George Herman 'Babe' Ruth)
Ruth Taylor
Mildred Tobin
William Sheer
Harry Knight
Margaret Seddon
Babe's Mother
Frances Victory
Pigtails
James A. Marcus
Simon Tobin
Ralf Harolde
John Tobin (as Ralph Harolds)
Charles Byer
David Talmadge (as Charles Burt)
George Halpin
Doc Hedges / The Constable / Dog Catcher
William J. Gross
Eliar Lott
Walter Lawrence
Tony Marino
Ann Brody
Mrs. Tony Marino (as Anne Brodie)
Ricca Allen
Almira Worters
Sammy Blum
Jimbo Jones (as Sam Blum)
Ethel Kerwin
Kitty Wilson
Tom Cameron
Deacon Flack (as Thomas Cameron)
Charles J. Hunt
Reverend David Talmadge